GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs703842 | 1 | rs10747783 | chr12:58176614 | FAM119B | chr12:58166383-58176323:+ | 0.43 | 10.56 | 7.05E-25 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10747783 | chr12:58176614 | TSFM | chr12:58176536-58191367:+ | -0.35 | -10.37 | 4.65E-24 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10747783 | chr12:58176614 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.18 | -5.02 | 6.04E-7 | Multiple sclerosis |
| BRCA | cis | rs9633740 | 1 | rs10748526 | chr10:82273079 | DYDC1 | chr10:82095864-82116511:- | 0.16 | 4.11 | 4.21E-5 | Post bronchodilator FEV1 |
| BRCA | cis | rs9633740 | 1 | rs10749609 | chr10:82249752 | DYDC1 | chr10:82095864-82116511:- | 0.15 | 3.7 | 0.000226 | Post bronchodilator FEV1 |
| BRCA | cis | rs2275426 | 1 | rs10749860 | chr1:46328210 | CCDC163P | chr1:45960581-45965646:- | -0.39 | -11.71 | 7.32E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10749860 | chr1:46328210 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.54 | 0.000424 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10749860 | chr1:46328210 | MUTYH | chr1:45794915-45806142:- | 0.13 | 5.11 | 3.87E-7 | Body mass index |
| BRCA | cis | rs10894147 | 1 | rs10750422 | chr11:129692580 | NFRKB | chr11:129733671-129765490:- | 0.17 | 3.53 | 0.000429 | Obesity-related traits |
| BRCA | cis | rs10894147 | 1 | rs10750422 | chr11:129692580 | ST14 | chr11:130029682-130080256:+ | 0.18 | 4.66 | 3.64E-6 | Obesity-related traits |
| BRCA | cis | rs10894147 | 1 | rs10750422 | chr11:129692580 | ZBTB44 | chr11:130096576-130184607:- | 0.14 | 3.45 | 0.000577 | Obesity-related traits |
| BRCA | cis | rs6684514 | 1 | rs10752615 | chr1:156248609 | BGLAP | chr1:156182784-156213112:+ | 0.2 | 5.36 | 1.02E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs7667 | 1 | rs10753559 | chr1:19698026 | CAPZB | chr1:19665274-19811992:- | -0.12 | -3.68 | 0.000241 | Crohn's disease and psoriasis |
| BRCA | cis | rs7667 | 1 | rs10753559 | chr1:19698026 | NBL1 | chr1:19923467-19984945:+ | -0.11 | -3.72 | 0.000212 | Crohn's disease and psoriasis |
| BRCA | cis | rs7667 | 1 | rs10753559 | chr1:19698026 | PQLC2 | chr1:19638740-19655793:+ | -0.1 | -3.45 | 0.000591 | Crohn's disease and psoriasis |